Endocrine Abstracts

Introduction: Thyroid nodules are common in population. High resolution ultrasound and fine needle aspiration biopsy (FNAB) are advised as the first line diagnostic methods. Bethesda classification system is used to provide standardization of cytologic reports. We aimed to evaluate ultrasound guided FNAB results in a mild-to-moderate iodine deficient city of Turkey.Methods: The patients (n=520), who underwent FNAB between December 2011 and Decem...

Introduction: We aimed to investigate the homeostasis model assessment of insulin resistance (HOMA-IR) and relation of HOMA-IR with age, sex and body mass index (BMI) and the prevalence of diabetes in Turkish population of different regions.Methods: Cross-sectional observational study was done in the frame of Turkish prevalence of insulin resistance multicenter study. The study sample consisted of volunteers from seven different regions of Turkey. Weight...

Introduction: Inferior petrosal sinus sampling for ACTH is the current gold standard test for the differentiation of pituitary Cushing disease from the ectopic ACTH syndrome. Early studies with İPSS reported a diagnostic sensitive and specificity approaching 100%, additional experience has shown a false negative rate of 1-10%. This has been due to either technical problem with unsuccessful petrosal sinus catheterization or anomalous venous drainage of the pituitary. The ...

Objective: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that affects 5–10% of women of reproductive age. In various studies, it was found to be associated with subclinical hypothyroidism. Serum TSH levels were also reported to be increased in obese individuals. In order to define the impact of obesity on the subclinical hypothyroidism observed in patients with PCOS, we aimed to investigate subclinical hypothyroidism both in lean and overweight...

Cortex protecting surgery for bilateral pheochromocytoma protects the patient from adrenal insufficiency. Risk of relapse is low. 35 years old woman had paroxysmal seizures and hypertension crises for the last year which became more frequent in the last 10 days. She had thyroidectomy and under the use of levothyroxine the patient. Because of a nodule on ultrasonography and paternal history of MEN 2A which led to a check of calcitonin level that resulted 8 times higher than the...

Although primary hyperparathyroidism (PHPT) is seen in young women at 8/million ratio, it is more rare to be seen with pregnancy. If diagnosed and not treated during pregnancy, the mother may have nephrolithiasis, hypercalcemic crisis, hypertension, preeclampsia, pancreatitis, death and intrauterine growth retardation in the fetus, low birth weight, preterm delivery, intrauterine death or postpartum tetany. Forty-year-old woman at the 14th week of gestation was diagnosed with ...

Introduction: A significance of chronic hyperglycaemia related to the rising intraocular pressure are discussed in the previous studies. The purpose of the present study was to investigate changes of intraocular pressure induced by acute changes of glucose levels during oral glucose tolerance test in non-diabetic subjects.Methods: Fifty-one individuals who were needed to be screened for diabetes, were scheduled for oral glucose tolerance test according t...

Introduction: Type two diabetes (T2DM), is the most common form of diabetes and known to be associated with low-grade inflammation. Since TLR-4 plays an important role in bacteriel recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways we aimed of to test whether TLR-4 gene polymorphism plays a protective role in the development of T2DM in a pilot Turkish population.Description of methods/design: Blood samples were collected f...

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress.The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients.Method: A case–control study was performed in 225 acromegalic patients (F/M: 116/1...

Leptin hormone is mainly secreted from adipose tissue and has an important role in energy metabolism. There have been very few studies examining effects of leptin on oxidant stress. The aim of the present study was to investigate whether leptin affects lipid peroxidation and antioxidant status in the brain of mice. Adult male Bulb-c mice were divided into two groups. Leptin was intraperitoneally administered to the first group at a dose of 40ug/animal for 5 days. Controls rece...